I have oral lichen planus for last 1 year. pl tell me some medication ? - oral lichen planus more condition_symptoms
Try homeopathy "abchomeopathy.com" maybe I can help you, an experienced homeopath in your area or consult a homeopath Fame this site consulting staff via e-mail.
Try it with a healthy diet and the avoidance of pork or anything that can cause your body to produce heat.
Friday, December 18, 2009
Oral Lichen Planus More Condition_symptoms I Have Oral Lichen Planus For Last 1 Year. Pl Tell Me Some Medication ?
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Lichen Planus (OLP) is a chronic inflammatory disease, bilateral white stripes, papules or plaques on the oral mucosa, tongue and gums. Redness, erosions, and blisters may or may not be available.
Pathophysiology
Current data suggest that OLP a T-cell-mediated autoimmune disease in which CD8 + T lymphocytes autocytotoxic induce apoptosis of epithelial cells, which is the oral route.
The dense subepithelial mononuclear infiltrate in OLP is consist of T-cells and macrophages, and a greater number of T cells within the epithelium. Most T cells in the epithelium and adjacent damaged keratinocytes activated CD8 + lymphocytes. Therefore, the early formation of OLP lesions, the CD8 + T cells recognize an antigen with major histocompatibility complex is associated complex (MHC) class I on keratinocytes. After the antigen recognition and activation, T lymphocytes, CD8 + cytotoxic can induce apoptosis of keratinocytes. Release Activated CD8 + T cells (and possibly keratinocytes) May cytokines, the lymphocytes in the development of a lesion drag.
OLP lesions contained the cytokine tumor necrosis factor (TNF)-alpha (Younes, 1996; Sklavounou rose, 2000). Basal keratinocytes and T cells in the subepithelial infiltrate express TNF in situ (Khan, 2003; Thongprasom, 2006). Expressing keratinocytes and lymphocytes in lichen planus skin high p55 TNF receptor, TNF-RI (Simon, 1997). T-lymphocytes in the PLO include TNF mRNA and secreted TNF in vitro (Simark-Mattsson, 1999). Serum and saliva concentrations of TNF are elevated in patients with OLP (Karagouni, 1994; Sugerman, 1996; Sklavounou, 2004, Rhodes, 2005). TNF polymorphisms were identified in patients with OLP and can develop new skin lesions (Carrozzo, 2004) to contribute. The PLO has been successful (with thalidomide Dereure, 1996; treated Shirt, 2000), while thalidomide is known to suppress the production of TNF
The lichen planus antigen is unknown, although it) may be a peptide (or modified peptide, in this case really Lichen Planus is an autoimmune disease. The role of autoimmunity in the pathogenesis Suppotransmitted by many autoimmune features of the PLO, including the chronic, adult-onset diabetes, a preference for women with other autoimmune diseases, tissue casual lichen associations depressed immune suppressor activity in patients with OHA, and the presence of clonal T autocytotoxic planus. The expression or exposure of the lichen planus antigen is by drugs (lichenoid drug reaction), which induce contact allergens in dental restorative materials or toothpastes reaction (contact hypersensitivity), mechanical trauma (Koebner phenomenon), viral infections or other unknown officers.
There is currently no cure, although several agents have been tried. Thanks to use of its capacity of malignant transformation in these patients to remain in the monitoring of long-term top. Non-surgical treatment of lichen planus is the use of corticosteroids, retinoids, griseofulvin and cyclosporin. Cryosurgery and laser ablation of carbon dioxide planus have been proposed for the surgical treatment of oral lichen. However, the split was not a priority approachTreatment because it is an inflammatory disease that can recur. In addition, surgery is not for the types of erosion and atrophic, because it erodes the surface epithelium. The surgical treatment is for the record, such as skin changes, such as the epithelium of the affected area can be easily removed. However, it is likely that an operation is planus limited use in the treatment of oral lichen. Patients should be monitored regularly, especially with forms of erosion or atrophy and those who have a history of alcohol and tobacco and snuff, because the injury undergo malignant transformation in May after a long time.
Oral Lichen Planus was a few months to several years kenalong gel clear.Topical (steroids) is also a helpful.But hydroxychloroquine ideal.Oral taken under the supervision of a dermatologist.
Oral Lichen Planus was a few months to several years kenalong gel clear.Topical (steroids) is also a helpful.But hydroxychloroquine ideal.Oral taken under the supervision of a dermatologist.
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